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Bianca R. Mothé

Bianca R. Mothé

Professor of Biological Sciences

Office: CRA 6117

Bianca R. Mothé

Ph.D. Molecular and Cellular Pathology 2002: University of Wisconsin-Madison. Dr. Mothé started her appointment at CSUSM in Fall 2003. Dr. Mothé conducted her postdoctoral work at Epimmune, Inc in San Diego, CA. Her areas of specialization are immunology and virology, with research interests in designing novel vaccines for rapidly mutating pathogens, including HIV and SIV.






Walsh, S.R., Gillis, J., Peters, B., Mothé, B.R., Sidney, J., Sette, A., Johnson, R.P. Diverse recognition of conserved orthopoxvirus CD8+ T cell epitopes in vaccinated rhesus macaques. Vaccine. 2009 Jun 14. [Epub ahead of print]

Dow, C.#, Oseroff, C., Peters, B., Nance-Sotelo, C.#, Sidney, J., Buchmeier, M., Sette, A., Mothé, B.R. Lymphocytic choriomeningitis virus infection yields overlapping CD4+ and CD8+ T-cell responses. Journal of Virology. 2008 Dec;82(23):11734-41. Epub 2008 Oct 1.

Wang, P., Sidney, J., Dow, C.#Mothé, B., Sette, A., Peters, B. A systematic assessment of MHC class II peptide binding predictions and evaluation of a consensus approach. PLoS Comput Biol. 2008 Apr 4;4(4):e1000048.

Schneidewind, A., Brockman, M.A., Sidney, J., Wang, Y.E., Chen, H., Suscovich, T.J., Li, B., Adam, R.I., Allgaier, R.L., Mothé, B.R., Kuntzen, T., Oniangue-Ndza, C., Trocha, A., Yu, X.G., Brander, C., Sette, A., Walker, B.D., Allen, T.M. Structural and Functional Constraints Limit Options for CTL Escape in the Immunodominant HLA-B27 Restricted Epitope in HIV-1 Capsid. Journal of Virology. 2008 Jun;82(11):5594-605. Epub 2008 Apr 2.

Mothé, B.R., Stewart, B.#, Oseroff, C., Bui, H.-H., Stogiera, S.#, Garcia, Z., Dow, C.,  Rodriguez-Carreno, M.P., Kotturi, M., Pasquetto, V., Botten, J., Crotty, S., Grey, H., Janssen, E.,  Buchmeier, M.,  Sette, A. Chronic Lymphocytic Choriomeningitis Virus Infection Actively Down-Regulates CD4+ T Cell Responses Directed against a Broad Range of Epitopes. Journal of  Immunology. 2007 Jul 15;179(2):1058-67.

Bui, H.H., Botten, J., Fusseder, N., Pasquetto, V., Mothé, B., Buchmeier, M.J., Sette, A. Protein sequence database for pathogenic arenaviruses. Immunome Res. 2007 Feb 8;3:1.

Botten, J., Alexander, J., Pasquetto, V., Sidney, J., Barrowman, P., Ting, J., Peters, B., Southwood, S., Stewart#, B., Rodriguez-Carreno, M.P., Mothé, B., Whitton, J.L., Sette, A., Buchmeier, M.J. Identification of protective Lassa virus epitopes that are restricted by HLA-A2. Journal of Virology. 2006 Sep;80(17):8351-61.

Lichterfeld, M., Williams, K.L., Mui, S.K., Shah, S.S., Mothé, B.R., Sette, A., Kim, A., Johnston, M.N., Burgett, N., Frahm, N., Cohen, D., Brander, C., Rosenberg, E.S., Walker, B.D., Altfeld, M., Yu, X.G.T cell receptor cross-recognition of an HIV-1 CD8+ T cell epitope presented by closely related alleles from the HLA-A3 superfamily. International Immunology. 2006 Jul;18(7):1179-88. Epub 2006 Jun 13.

Fuller, D.H., Wu, M.S., McMahon, C.W.,  Rajakumar, P.A., Shipley, T.,  Fuller, J.T., Allen, T.M., Trichel, A.M.,  Mothé, B.R., Rudersdorf, R., Guzman, J., Haynes, J.R., Watkins, D.I., Murphey-Corb, M. Therapeutic DNA immunization induces persistent control of simian AIDS after discontinuation of antiretroviral therapy. Virology. 2006 Apr 25;348(1):200-15. Epub 2006 Jan 24.

Schulze zur Wiesch, J., Lauer, G.M,, Day, C.L,, Kim, A.Y., Ouchi, K., Duncan, J.E., Wurcel, A.G., Timm, J., Jones, A.M., Mothé, B., Allen, T.M., McGovern, B., Lewis-Ximenez, L., Sidney, J., Sette, A., Chung, R.T., Walker, B.D.  Broad repertoire of the CD4+ Th cell response in spontaneously controlled hepatitis C virus infection includes dominant and highly promiscuous epitopes. Journal of Immunology. 2005 Sep 15;175(6):3603-13. 

Peters, B., Bui, H.H., Sidney, J., Weng, Z., Loffredo, J.T., Watkins, D.I., Mothé, B.R., Sette, A.  A computational resource for the prediction of peptide binding to Indian rhesus macaque MHC class I molecules. Vaccine. 2005 Nov 1;23(45):5212-24. Epub 2005 Aug 18.

Geisbert, T.W., Jones, S., Fritz, E.A., Shurtleff, A.C., Geisbert, J.B., Liebscher, R., Grolla, A., Stroher, U., Fernando, L., Daddario, K.M., Guttieri, M.C., Mothe, B.R., Larsen, T., Hensley, L.E., Jahrling, P.B., Feldmann, H. Development of a new vaccine for the prevention of Lassa fever. PLoS Med. 2005 Jun;2(6):e183. Epub 2005 Jun 28. 

Bui, H.H., Sidney, J., Peters, B., Sathiamurthy, M., Sinichi, A., Purton, K.A., Mothe, B.R., Chisari, F.V., Watkins, D.I., Sette, A. Automated generation and evaluation of specific MHC binding predictive tools: ARB matrix applications. Immunogenetics. 2005 Jun;57(5):304-14. Epub 2005 May 3. 

Altfeld, M., Allen, T.M., Kalife, E., Frahm, N., Addo, M.M., Mothe, B.R., Rathod, A., Reyor, L., Harlow, J., Yu, X., Perkins, B., Sidney, J., Alter, G., Lichterfeld, M., Sette, A., Rosenberg, E.S., Goulder, P.J.R., Brander, C., Walker, B.D. The majority of currently circulating HIV-1 clade B viruses fail to prime CTL responses against an otherwise immunodominant HLA-A2-restricted epitope. Journal of Virology. 2005 Apr;79(8):5000-5.

Tangri, S., Mothé, B.R., Eisenbraun, J., Sidney, J., Southwood, S., Briggs, K., Zinckgraf, J., Bilsel, P., Newman, M., Chesnut, R., LiCalsi, C., Sette, A. Rationally Engineered Therapeutic Proteins with Reduce Immunogenicity. Journal of Immunology. 2005 Mar 15;174(6):3187-96.

Sette, A, Sidney, J., Bui, H.-H., del Guercio, M.-F., Alexander, J., Loffredo, J., Watkins, D.I., and Mothé, B.R. Characterization of the peptide-binding specificity of Mamu-A*11 results in the identification of SIV-derived epitopes and interspecies cross-reactivity. Immunogenetics. 2005 Apr;57(1-2):53-68. Epub 2005 Mar 4.

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