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Bianca Romina Mothé

Bianca Romina Mothé

Professor of Biological Sciences


Office: Science hall 2 room 113
Hours: Mondays 9-10 am Face to Face or via zoom (email me).Alternatively, email me to schedule an appt at another time.

Bianca Romina Mothé

Dr. Mothé started her appointment at CSUSM in Fall 2003. Dr. Mothé conducted her postdoctoral work at Epimmune, Inc in San Diego, CA. Her areas of specialization are immunology and virology, with research interests in designing novel vaccines for rapidly mutating pathogens, including HIV and SIV. Dr. Mothé is also interested in stem cell immunogenetics.

Education

Ph.D. in Molecular and Cellular Biology, University of Wisconsin- Madison

B.S. in Biochemistry and Theatre Arts (Dance), Beloit College

Research

Dr. Mothé is interested in the immunogenetics of Major Histocompatibility Complex (MHC) genes in different systems, including viral and bacterial infection, as well as the expression of MHC genes in stem cells.

 

Courses

Vitae

Publications

# denotes Mothé’s student

Lopez#, C.A., Rocha, J., Chapman, M., Baum, S., Rocha, J., Wallace, S., Lawler, B.R. and Mothé, B.R., Strengthening STEM Education through Community Partnerships. SCIENCE EDUCATION & CIVIC ENGAGEMENT. 2016. (https://seceij.net/seceij/summer16/strengthening_s.html)

 

Mothé BR,, Lindestam Arlehamn CS, Dow C, Dillon MB, Wiseman RW, Bohn P, Karl J, Golden NA, Gilpin T#, Foreman TW, Rodgers MA, Mehra S, Scriba TJ, Flynn JL, Kaushal D, O’Connor DH,  Sette A. The TB-specific CD4+ T cell immune repertoire in both cynomolgus and rhesus macaques largely overlap with humans. Tuberculosis (Edinb). 2015 Aug 28. pii: S1472-9792(15)30061-5. doi: 10.1016/j.tube.2015.07.005. [Epub ahead of print]

 

Dow C, Henderson R#, Sette A, Mothé BR. CD4+ T cell inhibitory ligands: A tool for characterizing dysfunctional CD4+ T cells during chronic infection. Immunology. 2013 Apr 9. doi: 10.1111/imm.12109. [Epub ahead of print] PMID: 23566283

 

Mothé BR, Southwood S, Sidney J, English AM, Wriston A, Hoof I#, Shabanowitz J, Hunt DF, Sette A. Peptide-binding motifs associated with MHC molecules common in Chinese rhesus macaques are analogous to those of human HLA supertypes and include HLA-B27-like alleles. Immunogenetics. 2013 Feb 17. [Epub ahead of print]

 

Sette, A., Sidney, J., Southwood, S., Moore, C. #, Berry, J. #, Dow, C. #, Bradley,K., Hoof, I. #, Lewis, M.G., Hildebrand, W.H., McMurtrey,C.P., Wilson, N.A., Watkins, D.I., Mothé, B.R. A shared MHC supertype motif emerges by convergent evolution in macaques and mice, but is totally absent in human MHC molecules. Immunogenetics. 2012 Jun;64(6):421-34. Epub 2012 Feb 10.

 

Moore, C. #, Sidney, J., English, A.M., Wriston, A., Hunt, D.F., Shabanowitz, J., Southwood, S., Bradley, K., Lafont, B.A., Mothé, B.R., Sette, A. Identification of the peptide-binding motif recognized by the pigtail macaque class I MHC molecule Mane-A1*082:01 (Mane A*0301). Immunogenetics. 2012 Jun;64(6):461-8. Epub 2012 Jan 26.

 

Mothé, B.R., Knox, V., Strother, D. Developing a Science Center at Twin Oaks Elementary School: A STEM Community Service Learning Project at CSUSM. UCSD Sixth College.

 

Wambua, D. #, Henderson, R. #, Solomon, C. #, Hunter, M., Marx, P., Sette, A., Mothé, B.R.

SIV-infected Chinese-origin rhesus macaques express specific MHC class I alleles in either elite controllers or normal progressors. J Med Primatol. 2011 Aug;40(4):244-7. doi: 10.1111/j.1600-0684.2011.00487.x.

 

Southwood, S., Solomon. C.#, Hoof, H.#, Rudersdorf, R., Sidney, S., Peters, B., Wahl, A., Hawkins, O., Hildebrand, W., Mothé, B.R., Sette, A. Functional analysis of frequently expressed Chinese rhesus macaque MHC class I molecules Mamu-A*02601 and Mamu-B*08301 reveal HLA-A2 and HLA-A3 supertypic specificities, respectively. 2011 May;63(5):275-90. Epub 2011 Jan 28.

 

Botten, J., Sidney, J., Mothé, B.R., Peters, B., Sette, A., Kotturi, M.F. Coverage of related pathogenic species by multivalent and cross-protective vaccine design: arenaviruses as a model system. Microbiol Mol Biol Rev. 2010 Jun;74(2):157-70.

 

Solomon, C. #, Southwood, S., Hoof, I. #, Rudersdorf, R., Peters, B., Sidney, J., Pinilla, C., Marcondes, M.C.G., Ling, L., Marx, P., Sette, A., Mothé, B.R. The most common Chinese rhesus macaque MHC class I molecule shares peptide binding repertoire with the HLA B7 supertype. Immunogenetics. 2010 Jul;62(7):451-64. Epub 2010 May 18.

 

Walsh, S.R., Gillis, J., Peters, B., Mothé, B.R., Sidney, J., Sette, A., Johnson, R.P. Diverse recognition of conserved orthopoxvirus CD8+ T cell epitopes in vaccinated rhesus macaques. Vaccine. 2009 Aug 6;27(36):4990-5000. Epub 2009 Jun 14.

 

Dow, C. #, Oseroff, C., Peters, B., Nance-Sotelo, C., Sidney, J., Buchmeier, M., Sette, A, Mothé, B.R. Lymphocytic choriomeningitis virus infection yields overlapping CD4+ and CD8+ T-cell responses. Journal of Virology. 2008 Dec;82(23):11734-41. Epub 2008 Oct 1.

 

Wang, P., Sidney, J., Dow, C., Mothé, B., Sette, A., Peters, B. A systematic assessment of MHC class II peptide binding predictions and evaluation of a consensus approach. PLoS Comput Biol. 2008 Apr 4;4(4):e1000048.

 

Schneidewind, A., Brockman, M.A., Sidney, J., Wang, Y.E., Chen, H., Suscovich, T.J., Li, B., Adam, R.I., Allgaier, R.L., Mothé, B.R., Kuntzen, T., Oniangue-Ndza, C., Trocha, A., Yu, X.G., Brander, C., Sette, A., Walker, B.D., Allen, T.M. Structural and Functional Constraints Limit Options for CTL Escape in the Immunodominant HLA-B27 Restricted Epitope in HIV-1 Capsid. Journal of Virology. 2008 Jun;82(11):5594-605. Epub 2008 Apr 2.

 

Mothé, B.R., Stewart, B.#, Oseroff, C., Bui, H.-H., Stogiera, S.#, Garcia, Z., Dow, C.,  Rodriguez-Carreno, M.P., Kotturi, M., Pasquetto, V., Botten, J., Crotty, S., Grey, H., Janssen, E.,  Buchmeier, M.,  Sette, A. Chronic Lymphocytic Choriomeningitis Virus Infection Actively Down-Regulates CD4+ T Cell Responses Directed against a Broad Range of Epitopes. Journal of  Immunology. 2007 Jul 15;179(2):1058-67.

 

Bui, H.H., Botten, J., Fusseder, N., Pasquetto, V., Mothé, B., Buchmeier, M.J., Sette, A. Protein sequence database for pathogenic arenaviruses. Immunome Res. 2007 Feb 8;3:1.

 

Botten, J., Alexander, J., Pasquetto, V., Sidney, J., Barrowman, P., Ting, J., Peters, B., Southwood, S., Stewart#, B., Rodriguez-Carreno, M.P., Mothé, B., Whitton, J.L., Sette, A., Buchmeier, M.J. Identification of protective Lassa virus epitopes that are restricted by HLA-A2. Journal of Virology. 2006 Sep;80(17):8351-61.

 

Lichterfeld, M., Williams, K.L., Mui, S.K., Shah, S.S., Mothé, B.R., Sette, A., Kim, A., Johnston, M.N., Burgett, N., Frahm, N., Cohen, D., Brander, C., Rosenberg, E.S., Walker, B.D., Altfeld, M., Yu, X.G.T cell receptor cross-recognition of an HIV-1 CD8+ T cell epitope presented by closely related alleles from the HLA-A3 superfamily. International Immunology. 2006 Jul;18(7):1179-88. Epub 2006 Jun 13.

 

Fuller, D.H., Wu, M.S., McMahon, C.W.,  Rajakumar, P.A., Shipley, T.,  Fuller, J.T., Allen, T.M., Trichel, A.M.,  Mothé, B.R., Rudersdorf, R., Guzman, J., Haynes, J.R., Watkins, D.I., Murphey-Corb, M. Therapeutic DNA immunization induces persistent control of simian AIDS after discontinuation of antiretroviral therapy. Virology. 2006 Apr 25;348(1):200-15. Epub 2006 Jan 24.

 

Schulze zur Wiesch, J., Lauer, G.M, Day, C.L,, Kim, A.Y., Ouchi, K., Duncan, J.E., Wurcel, A.G., Timm, J., Jones, A.M., Mothé, B., Allen, T.M., McGovern, B., Lewis-Ximenez, L., Sidney, J., Sette, A., Chung, R.T., Walker, B.D.  Broad repertoire of the CD4+ Th cell response in spontaneously controlled hepatitis C virus infection includes dominant and highly promiscuous epitopes. Journal of Immunology. 2005 Sep 15;175(6):3603-13. 

 

Peters, B., Bui, H.H., Sidney, J., Weng, Z., Loffredo, J.T., Watkins, D.I., Mothé, B.R., Sette, A.  A computational resource for the prediction of peptide binding to Indian rhesus macaque MHC class I molecules. Vaccine. 2005 Nov 1;23(45):5212-24. Epub 2005 Aug 18. 

 

Geisbert, T.W., Jones, S., Fritz, E.A., Shurtleff, A.C., Geisbert, J.B., Liebscher, R., Grolla, A., Stroher, U., Fernando, L., Daddario, K.M., Guttieri, M.C., Mothé, B.R., Larsen, T., Hensley, L.E., Jahrling, P.B., Feldmann, H. Development of a new vaccine for the prevention of Lassa fever. PLoS Med. 2005 Jun;2(6):e183. Epub 2005 Jun 28.

 

Bui, H.H., Sidney, J., Peters, B., Sathiamurthy, M., Sinichi, A., Purton, K.A., Mothé, B.R., Chisari, F.V., Watkins, D.I., Sette, A. Automated generation and evaluation of specific MHC binding predictive tools: ARB matrix applications. Immunogenetics. 2005 Jun;57(5):304-14. Epub 2005 May 3.

 

Altfeld, M., Allen, T.M., Kalife, E., Frahm, N., Addo, M.M., Mothé, B.R., Rathod, A., Reyor, L., Harlow, J., Yu, X., Perkins, B., Sidney, J., Alter, G., Lichterfeld, M., Sette, A., Rosenberg, E.S., Goulder, P.J.R., Brander, C., Walker, B.D. The majority of currently circulating HIV-1 clade B viruses fail to prime CTL responses against an otherwise immunodominant HLA-A2-restricted epitope. Journal of Virology. 2005 Apr;79(8):5000-5.

 Tangri, S., Mothé, B.R., Eisenbraun, J., Sidney, J., Southwood, S., Briggs, K., Zinckgraf, J., Bilsel, P., Newman, M., Chesnut, R., LiCalsi, C., Sette, A. Rationally Engineered Therapeutic Proteins with Reduced Immunogenicity. Journal of Immunology. 2005 Mar 15;174(6):3187-96.

 

Sette, A., Sidney, J., Bui, H.-H., del Guercio, M.-F., Alexander, J., Loffredo, J., Watkins, D.I., and Mothé, B.R. Characterization of the peptide-binding specificity of Mamu-A*11 results in the identification of SIV-derived epitopes and interspecies cross-reactivity. Immunogenetics. 2005 Apr;57(1-2):53-68. Epub 2005 Mar 4.

 

Loffredo, J.T., Sidney, J., Wojewoda, C., Dodds, E., Napoé, G., Mothé, B.R., O’Connor, D.H., Wilson, N.A., Watkins, D.I., Sette, A., Seventeen New Simian Immunodeficiency Virus-Derived Cytotoxic T-Lymphocyte Epitopes Identified by Refinement of the Peptide-Binding Motif of the High Frequency Molecule, Mamu-A*02. Journal of Immunology. 2004 Oct 15;173(8):5064-76.

 

Allen, T.M., Altfeld, M., Yu, H.G., O’Sullivan, K.M., Lichterfeld, M., Lee, P.,  Le Gall, S., Mothé, B.R., Cohen, D.E., Freedberg, K.A., Sette, A.,  Rosenberg, E.S., Goulder, P.J.R., Brander, C., Walker, B.D. Selection. Transmission and Reversion of an Antigen Processing CTL Escape Mutation in HIV-1. Journal of Virology. 2004 Jul;78(13):7069-78.

 

Friedrich, T.C., Dodds, E.J., Yant, L., Rudersdorf, R., Cullen, C., Evans, D.T., Desrosiers, R.C., Mothé, B.R., Sidney, J., Sette, A., Kunstman, K., Wolinsky, S., Piatak, M., Lifson, J., McDermott, A., Wilson, N., O’Connor, D.H., Watkins, D.I. Reversion of transmitted cytotoxic T-lymphocyte (CTL) escape variant immunodeficiency viruses in vivoNature Medicine. 2004 Mar;10(3):275-81. Epub 2004 Feb 15.

 

O’Connor, D.H.*, Mothé, B.R.*, Weinfurter, J.*, Fuenger, S., Rehrauer, W., Jing,

P., Rudersdorf, R.A., Liebl, M.E., Krebs, K., Vasquez, J., Dodds, E., Loffredo, J., McDermott, A.B., Allen, T.M., Wang, C.,  Doxiadis, G.G.M., Montefiori, D.C., Burton, D.R., Allison, D.B., Wolinsky, S.M., Bontrop, R.E., Picker, L.J, Watkins, D.I.. MHC Class I Alleles Associated With Slow SIV Disease Progression Restrict Dominant Acute Phase Cytotoxic T Lymphocyte Responses. Journal of Virology, 2003 77:9029-40. (*co-1st author)

            *These authors contributed equally

 

Mothé, B.R., Weinfurter, J., Wang, C., Rehrauer, W., Wilson, N., Allen, T.M., Allison, D.B., Watkins, D.I. Expression of the MHC class I molecule Mamu-A*01 is Associated with Control of SIVmac239 Replication. Journal of Virology. 2003 Feb.; 77(4):2736-40

 

Allen, T.M., Jing, P., Calore, B., Horton, H., O’Connor, D.H., Hanke, T., Piekarczyk, M.,   Ruddersdorf, R., Mothé, B.R., Emerson, C., Wilson, N., Lifson, J.D., Belyakov, I.M., Berzofsky, J.A., Wang, C., Allison, D.B., Montefiori, D.C., Desrosiers, R.C.,Wolinsky, S., Kunstman, K.J., Altman, J.D., Sette, A., McMichael, A.J., Watkins, D.I. Effects of CTL Directed Against a Single SIV Gag CTL Epitope on the Course of SIVmac239 Infection. Journal of Virology. 2002 Oct.; 76(20):10507-11

 

Mothé, B.R., Sidney, J., Dzuris, J.L., Liebl, M.E., Fuenger, S., Watkins, D.I., and Sette, A.  Characterization of the peptide binding specificity of Mamu-B*17 and identification of Mamu-B*17-restricted epitopes derived from SIV proteins. Journal of Immunology. 2002. 169(1):210-219.

 

O'Connor, D.H., Allen, T.M., Vogel, T.U., Jing, P., DeSouza, I.P., Dodds, E., Dunphy, E.J., Melsaether, C., Mothé, B., Yamamoto, H., Horton, H., Wilson N, Hughes, A.L., Watkins, D.I. Acute phase cytotoxic T lymphocyte escape is a hallmark of simian immunodeficiency virus infection. Nature Medicine. 2002. May;8(5):493-9.

 

Mothé, B.R.*, Horton, H.*, Carter, D.K., Allen, T.M., Liebl, M.E., Skinner, P., Vogel, T.U., Fuenger, S., Vielhuber, K., Rehrauer, W., Wilson, N., Franchini, G., Altman, J.D., Haase, A., Picker, L.J., Allison, D.B., Watkins, D.I. Dominance of CD8 Responses Specific For Epitopes Bound by a Single MHC Class I Molecule During the Acute Phase of Viral Infection.  Journal of Virology, 2002 Jan.; 76 (2): 875-884.

            *These authors contributed equally

 

Allen, T.M., Mortara, L., Mothé, B.R., Liebl, M., Jing, P., Calore, B., Piekarczyk, M., Ruddersdorf, R., O’Connor, D.H., Fuller, D., Wang, X., Altman, J.D., Sette, A., Desrosiers, R., Sutter, G., Watkins, D.I. A DNA/MVA Vaccine Expressing Tat is Unable to Control Virus Replication in SIVmac239 Challenged Rhesus Macaques. Journal of Virology, 2002 April; 76 (8): 4108-12.

 

Allen, T.M.*, Mothé, B.R.*, Sydney, J., Jing, P., Dzuris, J.L., Liebl, M.E., Vogel, T.U., O’Connor, D.H., Wang, X., Wussow, M.C., Thomson, J.A., Altman, J.D., Watkins, D.I., Sette, A. CD8+ Lymphocytes From SIV-Infected Rhesus Macaques Recognize 27 Different Peptides Bound by the MHC Class I Molecule Mamu- A*01: Implications for Vaccine Design and Testing. Journal of Virology, 2001 Jan.; 75 (2): 738- 749.

            *These authors contributed equally

 

Sidney, J., Dzuris, J., Newman, M., Johnson, R.P., Amitindir, K., Appela,  E., Mothé, B.R., Watkins, D.I., Sette, A. Definition of the Mamu-A*01 peptide binding specificity: application to the identification of wild type and optimized ligands from SIV regulatory proteins. Journal of Immunology, 2000 Dec 1; 165(11):6387-99.

 

Allen, T.M., O'Connor, D.H., Jing, P., Dzuris,  J.L., Mothé, B.R., Vogel, T.U., Dunphy, E., Liebl, M.E., Emerson, C., Wilson, C., Kunstman, K.J., Wang, X., Allison, D.B., Hughes, A.L., Desrosiers, R.C., Altman, J.D., Wolinsky, S.M., Sette, A, Watkins, D.I.  Tat- Specific Cytotoxic T Lymphocytes  Select for SIV Escape Variants During Resolution of Primary Viraemia. Nature, 2000 Sep 21; 407(6802):386-90.

 

Allen, T.M., Vogel, T.U., Fuller, D.H., Mothé, B.R., Steffen, S., Boyson, J.E., Shipley, T., Fuller, J., Hanke, T., Sette, A., Altman, J.D., Moss, B., McMichael, A.J., Watkins, D.I. Induction of AIDS virus-specific CTL activity in fresh, unstimulated peripheral blood lymphocytes from rhesus macaques vaccinated with a DNA Prime/Modified vaccinia virus ankara boost regimen.  Journal of Immunology, 2000 May 1;164(9):4968-78.

 

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