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Dr. Jose Mendoza

Dr. Jose Mendoza

Professor of Chemistry

Office: SCI II 117

Dr. Jose Mendoza

Dr. Mendoza has investigated for a long time structure-function relationships of the "stress proteins", GroEL from E.coli, mammalian alpha-crystallin and Hsp60 from H.pylori.  These proteins, also referred to as molecular chaperones, protect cells from the adverse effects of stressful conditions (i.e. heat, oxidation, acid, etc.).  Recently, he has initiated studies of potential protective effects of thermally-sensitive enzymes by a combination of GroEL and osmolytes which are small organic molecules that accumulmate during cellular stress.  This research involves a combination of biochemical assays and fluorescence measurements of model enzymes.


Ph.D. Biochemistry, University of Texas Health Science Center at San Antonio, 1992

M.S. Organic Chemistry, University of Texas at El Paso, 1982

B.S. Chemistry, Instituto Tecnologico y de Estudios Superiores de Monterrey (Mexico), 1974





Mendoza, J.A., Rogers, E., Lorimer, G.H., and Horowitz, P.M. (1991) Chaperonins Facilitate the in Vitro Folding of Monomeric Mitochondrial Rhodanese. J. Biol. Chem. 266, 13044-13049.

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