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Dr. Kambiz Hamadani

Dr. Kambiz Hamadani

Assistant Professor of Chemistry and Biochemistry


Office: SCI2 331

Dr. Kambiz Hamadani

I am an interdisciplinary researcher, scholar, and educator with a penchant for challenging problems (like protein folding). I believe the most direct way into students minds is through their stomachs and that the greatest thing I can teach a student is how to learn for themselves. I fervently believe that science should be for everyone and try each day to make it so.

hamadani_2

Education

Post-doctoral training in Biochemistry at UC Berkeley. Advisors: Susan Marqusee and Jamie H.D. Cate 

Ph.D. in Biochemistry and Molecular Biology from UCLA. Advisor: Shimon Weiss

B.A. in Molecular and Cell Biology-Biochemistry from UC Berkeley. Advisors: Daniel E. Koshland Jr, Robert M. Glaeser, and Kenneth H. Downing

Research

Research in the Hamadani Lab centers on the study of protein folding and dynamics using single molecule fluorescence resonance energy transfer. This research is highly interdisciplinary and involves non-standard amino acid (NSAA) tagging of proteins within purified and reconstituted in-vitro translation systems (synthetic biochemistry), the bioconjugation of bright and photostable single molecule dyes efficiently onto these NSAA tags using click chemistry (chemical biology), and finally reading out the bioconformational state of the target biomolecules one at a time using ultrasensative fluorescence microscopes (biophysics). 

Courses

CHEM 105: General, Organic, and Biological Chemistry

CHEM 105L: General, Organic, and Biological Chemistry Lab

CHEM 341: General Biochemistry

CHEM 300: LIterature in Chemistry

 

Vitae

CURRENT POSITION
Assistant Professor, Dept. of Chemistry and Biochemistry, California State University San Marcos

EDUCATION
2002-2008 Ph.D., Biochemistry and Molecular Biology, University of California, Los Angeles. Graduate advisor:
Dr. Shimon Weiss. Dissertation Title: Non-equilibrium single molecule protein folding

1997-2001 B.A., Molecular and Cellular Biology-Biochemistry, University of California, Berkeley, Primary
Undergraduate advisors: Drs. Robert M. Glaeser and Kenneth H. Downing. Thesis title: 2D-electron
crystallography of a metastable photocycle intermediate of the G-coupled protein receptor bovine
rhodopsin. Secondary undergraduate advisor: Daniel E. Koshland Jr. Thesis title: Proteomics and
Models for Enzyme Cooperativity

OTHER PROFESSIONAL EXPERIENCE
2008-2013 Postdoctoral Scholar, Quantitative Biology Institute, University of California, Berkeley. Primary
Postdoctoral advisors: Drs. Jamie Cate & Susan Marqusee. Project Title: Developing novel chemical
biology tools to study co-translational protein folding using single molecule FRET.

Postdoctoral Collaborator: Dr. Carlos J. Bustamante. Project Title: Developing methods to monitor
transient heat evolution during biochemical catalysis.

2007-2008 Visiting Research Associate, College of Medicine Health Science Center, Texas A&M University.
Secondary Graduate advisor: Dr. Arthur E. Johnson. Project Title: Developing novel unnatural
florescent suppressor amino-acyl-tRNAs for smFRET studies of co-translational folding in a wheatgerm
extract-based translation system.

HONORS AND AWARDS
2018 BIOCOM Life Science Catalyst Award Nominee
2018 CSU Faculty Innovation and Leadership Award
2017 CSUSM College of Science and Math Outstanding Faculty-Student Research Collaboration Award
2015 CSUSM Celebration of Faculty Scholarship and Creative Activities Award Recipient
2005 Biotechnology Research and Education Program (BREP) - Graduate Research and Education in Adaptive bio-Technology (GREAT) Fellowship Finalist
2004 NSF Graduate Student Fellowship Program, Honorable Mention
2003 Departmental Fellowship, UCLA Dept. of Chemistry and Biochemistry
2001 Graduated with Honors, UC Berkeley
2001 Departmental Honors, UC Berkeley Dept. of Molecular and Cell Biology

PEER-REVIEWED PUBLICATIONS

  1. 2018 “Modulating long-range energetics via helix stabilization: a case study using T4 lysozyme”. Sabriya Rosemond, Kambiz M. Hamadani, Jamie HD Cate, and Susan Marqusee. Protein Science (accepted) 
  2. 2017 “An in-vitro tag-and-modify protein sample generation method for single-molecule fluorescence resonance energy transfer”. Kambiz M. Hamadani, Jesse Howe*, Madeleine Jensen, Peng Wu, Jamie HD Cate, and Susan Marqusee. Journal of Biological Chemistry 292(38):15636-15648 
  3. 2014 "The heat released during catalytic turnover enhances the diffusion of an enzyme”. Clement Riedel, Ronen Gabizon, Christian A.M. Wilson, Kambiz M. Hamadani, K. Tsekouras, Susan Marqusee, Steve Presse, and Carlos Bustamante Nature 517(7533):227-30 
  4. 2008 “Non-equilibrium single molecule protein folding in a co-axial mixer”. Kambiz M. Hamadani and Shimon Weiss. Biophysical Journal 95(1):352-365 
  5. 2008 “Single molecule protein folding kinetics in a co-axial microfluidic mixer”. Kambiz M. Hamadani and Shimon Weiss. Proceedings of the SPIE (eds. J. Enderlein, Z. Gryczynski, R. Erdmann) Vol. 6862:68620A 
  6. 2007 “Photobleaching pathways in single-molecule FRET experiments”. Xiangxu Kong, Eyal Nir, Kambiz M. Hamadani, Shimon Weiss. Journal of the American Chemical Society 129: 4643-4654
  7. 2006 “Shot-noise limited single molecule FRET histograms: comparison between theory and experiments”; Eyal Nir, Xavier Michalet, Kambiz M. Hamadani, Ted A. Laurence, Daniel Neuhauser, Yevgeniy Kovchegov, Shimon Weiss. Journal of Physical Chemistry B 110: 22103-22124 
  8. 2002 “Proteomics and models for enzyme cooperativity”. Daniel E. Koshland Jr., Kambiz M. Hamadani. Journal of Biological Chemistry 277(49): 46841

Complete List of Published Work in NCBI MyBibliography:

PROFESSIONAL SERVICE AND SOCIETY MEMBERSHIPS
2018-2021       Education Committee Member, Biophysical Society
2018-2021       Publications Committee Member, Biophysical Society
2017-Present  Member, International Union of Pure and Applied Chemistry
2015-Present  Member, American Chemical Society
2008-Present  Member, Biophysical Society

Peer Reviewed Publications

PEER-REVIEWED PUBLICATIONS

  1. 2018 “Modulating long-range energetics via helix stabilization: a case study using T4 lysozyme”. Sabriya Rosemond, Kambiz M. Hamadani, Jamie HD Cate, and Susan Marqusee. Protein Science (accepted) 
  2. 2017 “An in-vitro tag-and-modify protein sample generation method for single-molecule fluorescence resonance energy transfer”. Kambiz M. Hamadani, Jesse Howe*, Madeleine Jensen, Peng Wu, Jamie HD Cate, and Susan Marqusee. Journal of Biological Chemistry 292(38):15636-15648 
  3. 2014 "The heat released during catalytic turnover enhances the diffusion of an enzyme”. Clement Riedel, Ronen Gabizon, Christian A.M. Wilson, Kambiz M. Hamadani, K. Tsekouras, Susan Marqusee, Steve Presse, and Carlos Bustamante Nature 517(7533):227-30 
  4. 2008 “Non-equilibrium single molecule protein folding in a co-axial mixer”. Kambiz M. Hamadani and Shimon Weiss. Biophysical Journal 95(1):352-365 
  5. 2008 “Single molecule protein folding kinetics in a co-axial microfluidic mixer”. Kambiz M. Hamadani and Shimon Weiss. Proceedings of the SPIE (eds. J. Enderlein, Z. Gryczynski, R. Erdmann) Vol. 6862:68620A 
  6. 2007 “Photobleaching pathways in single-molecule FRET experiments”. Xiangxu Kong, Eyal Nir, Kambiz M. Hamadani, Shimon Weiss. Journal of the American Chemical Society 129: 4643-4654
  7. 2006 “Shot-noise limited single molecule FRET histograms: comparison between theory and experiments”; Eyal Nir, Xavier Michalet, Kambiz M. Hamadani, Ted A. Laurence, Daniel Neuhauser, Yevgeniy Kovchegov, Shimon Weiss. Journal of Physical Chemistry B 110: 22103-22124 
  8. 2002 “Proteomics and models for enzyme cooperativity”. Daniel E. Koshland Jr., Kambiz M. Hamadani. Journal of Biological Chemistry 277(49): 46841

Complete List of Published Work in NCBI MyBibliography:

Hamadani Lab