Dr. Julie Jameson received her Ph. D in Immunology and Virology at the University of Massachusetts Medical Center in Worchester, Massachusetts. She joined the Biology faculty at CSUSM in Fall 2012, after being Assistant Professor at The Scripps Research Institute in La Jolla. The research in her laboratory focuses on the function of T cells in infection and tissue repair. Recent studies in her laboratory have shown that obesity and type 2 diabetes impair T cell function in the murine skin resulting in wound healing complications. Now the laboratory is investigating how this devastating disease impacts the ability of T cells to fight infection and heal wounds in patients. The Jameson laboratory embraces translational research by taking findings from basic science studies into the clinic for investigation.
1990-1994 B.A. Biology, University of California, Santa Barbara, CA
1994-1999 Ph.D. Immunology and Virology, University of Massachusetts Medical Center, Worcester, MA
1999-2004 Research Associate, The Scripps Research Institute, La Jolla, CA
2004-2005 Senior Research Associate, The Scripps Research Institute, La Jolla, CA
2005-2012 Assistant Professor, The Scripps Research Institute, La Jolla, CA
2012-present Adjunct Assistant Professor, The Scripps Research Institute, La Jolla, CA
2012-present Assistant Professor, California State University, San Marcos
Jameson J., Cruz J. and Ennis F.A. (1998). Human Cytotoxic T-Lymphocyte Repertoire to Influenza A Viruses. J. Virol. 72:8682.
Rothman A.L., Yamada Y., Jameson J., Cruz J., West K., Green S. and Ennis F.A. (1998). Assessment of Human CD4+ and CD8+ T Lymphocyte Responses in Experimental Viral Vaccine Studies, p. 95-104. In Plotkin, S., Brown, F., and Horaud, F., (eds.), Preclinical and Clinical Development of New Vaccines. Dev. Biol. Stand. Basel, Karger.
Jameson J., Cruz J., Terajima M. and Ennis F.A. (1999). Human CD8+ and CD4+ T Lymphocyte Memory to Influenza A Viruses of Swine and Avian Species. J. Immunol. 162:7578.
Terajima M., Jameson J., Norman J., Cruz J. and Ennis F.A. (1999). High Yield Reassortant Influenza Vaccine Production Virus Has Mutation at an HLA-A2.1 Restricted CD8+ CTL Epitope on the NS1 Protein. Virol. 259:135.
Zivny J., DeFronzo M., Jarry W., Jameson J., Cruz J., Ennis F.A. and Rothman A.L. (1999) Partial Agonist Effect Influences the CTL Response to a Heterologous Dengue Virus Serotype. J Immunol. 163:2754.
Ennis F.A., Cruz J., Jameson J., Klein M., Burt D. and Thipphawong J. (1999) Augmentation of Human Influenza A Virus-Specific Cytotoxic T Lymphocyte Memory by Influenza Vaccine and Adjuvanted Carriers (ISCOMS). Virol. 259:256.
Maderazo E. G. and Jameson J. (2002). Infections and the Host, p. 1-29. In R.G. Topazian, M.H. Goldberg, and J.R. Hupp, (eds.), Oral and Maxillofacial Infections, Fourth Edition.
Jameson J., Ugarte K., Chen N., Yachi P., Fuchs E., Boismenu R. and Havran W.L. (2002). A Role for Skin gd T Cells in Wound Repair. Science. 296:747.
Jameson J., Witherden D. and Havran W.L. (2003). T-Cell Effector Mechanisms: gd and CD1d-Restricted Subsets. Curr Opin Immunol. 15:349.
Jameson J., Cauvi G., Witherden D. and Havran W.L. (2004). A Keratinocyte-Responsive gd TCR Is Necessary for Dendritic Epidermal T Cell Activation by Damaged Keratinocytes and Maintenance in the Epidermis. J Immunol. 172:3573.
Jameson J., Sharp L., Witherden D. and Havran W.L. (2004). Regulation of Skin Cell Homeostasis by Gamma Delta T Cells. Front. Biosci. 9:2640.
Sharp L.*, Jameson J.*, Cauvi G. and Havran W.L. (2005). Dendritic Epidermal T-Cells Regulate Skin Homeostasis Through Local Production of Insulin-like Growth Factor-1. Nat Immunol. 6:73. *Authors Contributed Equally
Jameson J., Cauvi G., Sharp L., Witherden D. and Havran W.L. (2005). gd T cell-induced Hyaluronan Production by Epithelial Cells Regulates Inflammation. J Exp Med. 201:1269.
Havran, W.L., Jameson, J.M. and Witherden D. (2005). Interactions between intraepithelial lymphocytes and neighboring epithelial cells. Am. J. Physiol. 289:G627.
Jameson, J. and Havran, W.L. (2007). Skin gd T cell functions in homeostasis and wound healing. Immunol. Rev. 215:114.
Terajima, M., Cruz, J., Leporati, A.M., Orphin, L., Babon, J.A., Co, M.D., Pazoles, P., Jameson, J., and Ennis, F.A. (2008). Influenza A virus subtype cross-reactive human CD8+ T cell responses to internal proteins in trivalent inactivated vaccines. J. Virol. 82:9283. PMCID: PMC2546892.
Mills, R.E., Taylor, K.R., Podshivalova, K., McKay, D.E., and Jameson, J.M. (2008). Defects in skin gd T cell function contribute to delayed wound repair in rapamycin-treated mice. J. Immunol. 181:3974. PMCID: PMC2547144.
Mills, R.E. and Jameson, J.M. (2009). T cell dependence on mTOR signaling. Cell Cycle 15:545.
Toulon, A., Breton, L., Tenenhaus, M., Bhavsar, D., Lanigan, C., Rudolph, R., Jameson, J., and Havran, W. (2009). A role for human skin-resident T cells in wound healing.
J Exp Med. 206:743. PMCID: PMC2715110.
Jameson, J.M., Cruz, J., Costanzo, A., Terajima, M., and Ennis, F.A. (2010). A role for the mevalonate pathway in the induction of subtype cross-reactive immunity to influenza A virus by human gd T lymphocytes. Cell. Immunol. 264:71. PMCID: 2905741.
Havran, W.L. and Jameson, J. (2010). Epidermal T cells and wound healing. J. Immunol. 184:5423.
Taylor, K., Mills, R., Costanzo, A., and Jameson, J. (2010). gd T cells are reduced and rendered unresponsive by hyperglycemia and chronic TNF-a in mouse models of obesity and metabolic disease. PLoS One. 5:e11422. PMCID: 2896399.
Taylor, K., Costanzo, A., and Jameson, J. (2011). Dysfunctional gd T cells contribute to impaired keratinocyte homeostasis in mouse models of obesity. J. Invest. Dermatol. 131:2409. PMCID: PMC3213272
Komori, K., Witherden, D.A., Kelly, R., Sendaydiego, K., Jameson, J.M., Teyton, L., and Havran, W.L. (2012). Dendritic epidermal gd T cell ligands are rapidly and locally expressed by keratinocytes following cutaneous wounding. J. Immunol. 188:2972.
Cheung, K., Taylor, K., and Jameson, J. (2012). Immunomodulation at epithelial sites by obesity and metabolic disease. Immunol. Res. 52:182.
McKay, D. and Jameson, J. (2012). Kidney transplantation and the ageing immune system. Nat. Rev. Nephrol. 8:700.
Costanzo, A., Taylor, K., Dutt, S., Han, P., Fujioka, K., and Jameson, J.M. (2015). Obesity impairs gd T cell homeostasis and antiviral function in humans. PLoS One. 10:e0120918. PMCID: PMC4365046.
Johnson, J., Costanzo, A., Gareau, M., Armando, A., Quehenberger, O., Jameson, J.M., and Olefsky, J. (2015). High Fat Diet Causes Depletion of Intestinal Eosinophils Associated With Intestinal Permeability. PLoS One. 10:e0122195. PMCID: PMC4383570.
Bonneville, M., Chen, Z., Dechanet-Merville, J., Fournie, J., Jameson, J.M., Lopez, R., Massaia, M., Silva-Santos, B., and Eberl, M. (2015). Chicago 2014- 30 years of gd T cells. Cell. Immunol. 296:3.
Cheung, K.P., Park, C., Clementsmith, Z., Limon, N., Johnson, A., Olefsky, J., and Jameson, J.M. (2016). Obesity-induced inflammation suppresses intestinal intraepithelial lymphocyte numbers and function. (Manuscript in preparation)